According to the National Interagency Fire Center, as of Wednesday, 81 large fires currently ablaze have scorched 1.6 million acres across 12 states.
The organization noted that there are more than 21,400 wildland firefighters and support personnel working to put out the fires.
Images taken from inside the effort showed raging infernos scorching trees and structures against dark orange skies.
Smoke pumped into the atmosphere from these fires – as well as wildfires in Canada – has affected cities on both coasts, forcing air quality warnings and advisories.
Officials warned that particulate matter pollution could be unhealthy for groups including sensitive individuals, small children, seniors, pregnant women and anyone with cardiovascular and respiratory problems like asthma or lung disease.
Residents were advised to decrease exposure and spend time indoors, though those in the thick of it could also be in danger from other chemicals as communities go up in flames.
While "PBS News Hour" reported Tuesday that there is not enough data on the effect of wildfire smoke to human health, doctors in California linked smoke pollution to a negative long-term impact on human health.
Lightning strikes set two of California's biggest fire complexes ablaze last year and this year – the almost 69,000-acre Tamarack Fire was sparked in the parched wilderness by lightning south of Lake Tahoe.
According to the National Weather Service, isolated storm development is forecast Wednesday for higher terrain in central Idaho and western Montana.
Elevated fire weather conditions are expected as dry and breezy conditions pick up winds over the northern Plains.
Excessive heat is covering much of the central third of the country and is expected to persist into the weekend over south-central states.
The Associated Press contributed to this report.